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Age and HER2 expression status affect MRI accuracy in predicting residual tumor extent after neo-adjuvant systemic treatment.
BACKGROUND Although recent studies suggest high accuracy of breast magnetic resonance imaging (MRI) in predicting residual tumor extent after neo-adjuvant systemic treatment (NST), its use is still controversial. In this study, we aimed to identify predictive factors of MRI accuracy after NST to determine a subgroup of patients in whom the use of MRI provides best additional benefit. MATERIAL...
متن کاملCancer in Botswana: the second wave of AIDS in Sub-Saharan Africa.
B A C a b S D c for the visiting team from the Massachusetts General os ital Cancer Center and our artners at the Medical School of the niversit of Botswana the rincess Marina os ital the Gaborone rivate os ital and the Botswana Ministr of ealth Departments of aMedicine and b adia on nco o Massac se s enera ospita oston Massac se s c ri am and omen s ospita oston Massac se s Disclosures of pote...
متن کاملH-NST Induces LEE Expression and the Formation of Attaching and Effacing Lesions in Enterohemorrhagic Escherichia coli
BACKGROUND Enteropathogenic E. coli (EPEC) and enterohemorrhagic E. coli are important causes of morbidity and mortality worldwide. These enteric pathogens contain a type III secretion system (T3SS) responsible for the attaching and effacing (A/E) lesion phenotype. The T3SS is encoded by the locus of enterocyte effacement (LEE) pathogenicity island. The H-NS-mediated repression of LEE expressio...
متن کاملNanostructured TiO2 thin films as porous cellular interfaces
We report the use of nanostructured TiO2 (NST) as porous cellular adhesion interfaces for microsystems. Integrated NST films and pad arrays with sponge-like morphology were fabricated by aqueous oxidation of Ti films followed by thermal annealing. Cell culture studies indicate significantly (t < 0.02 from the student’s t-test) greater initial attachment of mouse fibroblast cells on porous NST t...
متن کاملA global modulatory role for the Yersinia enterocolitica H-NS protein.
The H-NS protein plays a significant role in the modulation of gene expression in Gram-negative bacteria. Whereas isolation and characterization of hns mutants in Escherichia coli, Salmonella and Shigella represented critical steps to gain insight into the modulatory role of H-NS, it has hitherto not been possible to isolate hns mutants in Yersinia. The hns mutation is considered to be deleteri...
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